Identification of a molecular system that regulates growth cone membrane potential during growth cone guidance
نویسندگان
چکیده
منابع مشابه
Has electrical growth cone guidance found its potential?
Many neurobiologists spurn the existence and use of direct-current (DC) electric fields (EFs) in nervous system development and regeneration. This is despite direct measurement of EFs in embryos and adults, and evidence that EFs are required for normal development, dramatically influence the rate and direction of nerve growth in vitro, and promote nerve regeneration in vivo. The notion that gro...
متن کاملMaking the connection: Cytoskeletal rearrangements during growth cone guidance
One of the fundamental questions of neurobiology is how neurons acquire the intricate yet stereotyped pattern of connections characteristic of the adult nervous system. A century ago, Ramon y Cajal hypothesized that neurons grow by extending axons and dendrites through embryonic tissues guided by the expanded terminal structure that he named the growth cone. Two decades later, Granville Harriso...
متن کاملGrowth cone guidance in the zebrafish central nervous system.
The accessibility and simplicity of the zebrafish embryo have allowed researchers to make a detailed characterization of pathfinding by identifiable growth cones. The growth cones follow precise cell-specific pathways to their targets. Analyses of pathfinding in mutant and experimentally manipulated wild type embryos have shown that growth cones accomplish this by interacting with specific cell...
متن کاملGrowth cone dynamics during the migration of an identified commissural growth cone.
We have used time-lapse video microscopy to study the behavior of a neuron, Q1, that pioneers the posterior commissure of the embryonic grasshopper. Our goal is to use time-lapse video as a tool to acquire a precise picture of normal development over time, and thereby identify stereotypic activities that might indicate important interactions necessary for proper formation of the commissure. We ...
متن کاملDifferential Role of PTEN Phosphatase in Chemotactic Growth Cone Guidance*
Negatively targeting the tumor suppressor and phosphoinositide phosphatase PTEN (phosphatase and tensin homologue) promotes axon regrowth after injury. How PTEN functions in axon guidance has remained unknown. Here we report the differential role of PTEN in chemotactic guidance of axonal growth cones. Down-regulating PTEN expression in Xenopus laevis spinal neurons selectively abolished growth ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2011
ISSN: 1471-2202
DOI: 10.1186/1471-2202-12-s1-p280